Research over the past
few years has clearly demonstrated that infertile men have an increased
frequency of chromosomal abnormalities. These findings are further co-related
by increased frequency of chromosomal abnormalities found in newborns and
fetuses born from the pregnancies conceived by ICSI. As reported in literature,
in half of the couples with unsuccessful pregnancy, the cause of infertility is
male related, and of them in about 30% genetic factors with abnormal semen
parameters should be considered. Chromosomal abnormality is one of the
important cause of male infertility because it disrupts genes involved in the
genetic control of human spermatogenesis 10,11,12,13.
study, the incidence of chromosomal abnormalities in azoospermic group 16.3%
was higher than in oligozoospermic 9.5% with an overall occurrence of 11.2 %
Table I, clearly demonstrated an inverse correlation between chromosomal
anomalies and sperm count. Also these findings were comparable to the
literature data varying from 2.2 – 22.6% 3,4,11,13. No chromosomal
abnormality had been found in control group (P0.05).
conclusion, the occurrence of major chromosomal abnormalities (11.2%) in
infertile males in our study strongly suggests the genetic testing and
counseling of infertile couples prior to the use ICSI treatment for to minimize
the risk of propagation of chromosomal abnormalities into the next generation.
It should be mandatory and included in routine investigations of infertile men,
before using assisted reproduction techniques (ARTs). 13,30.